About Prescription Vetoryl Capsules
Vetoryl is a prescription medication in a capsule form for use in dogs and indicated for the treatment of pituitary-dependent hyperadrenocorticism (Cushing's Disease) in dogs and the treatment of hyperadrenocorticism due to adrenocortical tumor in dogs. The active ingredient in Vetoryl is Trilostane.
Benefits of Vetoryl:
How Vetoryl Works
Vetoryl contains a drug that controls the adrenal gland's excess production of cortisol, a hormone released into the bloodstream during times of stress.
Vetoryl (Trilostane) is a competitive inhibitor of the enzyme 3-beta-hydroxysteroid dehydrogenase used in dogs for the treatment of pituitary dependent Cushing's Disease and Cushing's Disease due to adrenocortical tumors. It may be necessary to wait at least one month after discontinuing Lysodren before starting treatment with Vetoryl.
Vetoryl Dosage & Administration
Vetoryl is a prescription medication FDA approved for veterinary use in the treatment of Cushing's Disease. Vetoryl is indicated for use in pituitary-dependent hyperadrenocorticism. Vetoryl also has a Minor Use designation for treatment of Cushing's Disease caused by adrenal tumors.
Vetoryl is available as 5 mg capsules, 10mg capsules, 30 mg capsules, 60 mg capsules and 120 mg capsules. The usual initial starting dose to treat Cushing's Disease in dogs is 1.0 to 3.0 mg/pound given once a day based on body weight and capsule size.
For dogs at least 3.8 up to 10 lbs give one 10 mg capsules once a day.
For dogs at least 10 lbs up to 22 lbs give one 30 mg capsules once a day.
For dogs at least 22 lbs up to 44 lbs give one 60 mg capsule.
For dogs at least 44 lbs up to 88 lbs give one 120 mg capsule. For dogs at least 88 lbs up to 132 lbs give one 120 mg capsule and one 60 mg capsule, totaling 180 mg.
For dogs over 132 lbs give the appropriate combination of capsules.
Vetoryl should be given with food. After approximately 10 to 14 days the pet will need to be re-examined and dosage adjustments may be required. Pets may require further re-examination at 30 days, 90 days, and every 3 months thereafter.
Give this medication exactly as directed by your veterinarian. Give this medication with food. Do not open capsules and do not attempt to split or divide capsules. Wash your hands after use. Do not handle the capsules if you are pregnant or trying to become pregnant. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Store Vetoryl at controlled room temperature (77°F) with excursions to 86° F allowed. Keep this medication away from children and other pets.
Vetoryl Side Effects
If any of the following serious side effects occur, stop giving Vetoryl and seek emergency veterinary medical attention; an allergic reaction (difficulty breathing; swelling of the lips, tongue or face; hives), severe depression, bloody diarrhea, collapse, or other severe reactions. Other less serious side effects such as unexpected decrease in appetite, vomiting, diarrhea, and lethargy may occur. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal.
Before giving Vetoryl tell your veterinarian if your pet is also taking ACE inhibitors such as enalapril, potassium sparing diuretics such as spironolactone, ketoconazole, or potassium supplements. Talk to your veterinarian or pharmacist before giving any prescription or over the counter medicines or nutritional supplements.